Hi, I'm fairly new to organic chemistry (9 month or so now, no other experience in chemistry )and have synthesized amphetamine via the Al/Hg route a few dozen times in the last couple of months.
I was able to reduce up to 120g of P2NP in a 20L round bottom flask. The purity of the end product was phenomenal in the last syntheses.
Most of the time I only had to purify the amphetamine sulfate once pro forma with acetone because it was already so white.
I found the NaBH4/CuCl²-route interesting because I have a great deal of respect for working with mercury, it had already led to a violent exothermic reaction three times, a large amount was distributed throughout the room and I would like to do without it in future.
The reduction with NaBH4/CuCl² also allows a significantly higher yield with a flask that is only half the size.
So far I have synthesized three times. The first time 80g P2NP, the second time 200g P2NP and the last time 250g P2NP.
The last one was the best of all, as I managed to stick exactly to the temperatures.
What I should also mention is that in order to shorten the process of administering P2NP, I place the flask in a large container full of ice, which I then heat over a hotplate. I was able to fill the entire 250g of P2NP into the flask in a good three quarters of an hour without getting above the 60°C mark. Does this affect the reaction with the Borohydride?
Despite all the care taken, the sulfate has a somewhat sweet, pungent smell at the end, despite its snow-white color. The consistency is also much more crystalline, crunching softly when crushed.
I have cleaned it several times with acetone and DCM, filtered it in a Buchner funnel, etc.
It definitely seems that another salt has joined the sulfate.
Has something similar ever happened to you?
Is it possible that the Sodium Borohydride, if not completely dissolved, mixes with the amphetamine freebase and is converted to a sodium salt when neutralized with H²SO4?
The stuff also burns badly in the nose. A friend had watery nasal mucus running out of his nose for several minutes immediately after taking a drag.
And now the real question: if there is another salt in it, how or what method can I use to separate the two substances?
I'm slowly coming to the end of my tether.
Thank you in advance for your patience in reading the whole text
I am grateful for any advice.
Mr.Magic