One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale)

[G.Patton]

Temperature and pH have a strong influence on the reaction yield. You have to control temperature as described in the manual. Also, you should carry out acidifying very slowly to save your product. It also can cause side-products formation.

 

[Mystery_chemistry]

oki then what should the pH be before adding the base? according to the bars, there are 10 in 100% and I even think that more: / even if it goes up to 14, something will happen?

at the temperature won't it be better to keep all reactions in those 55-60? when reducing aluminum amalgam the temperature is so, why are we given a higher temperature here?

 

[Bartholomeus]

Do you already have any experience with this reaction?
Or did you already had any success with this reaction?
What was your yield?

 

[G.Patton]

It's okay, pay acidification procedure
because here is different reaction, there is no amalgam

 

[Mystery_chemistry]

I know, but I mean more about p2np which has a melting point of 63-65 degrees ... hence my question whether the reaction at 55 degrees throughout the reaction time will not be a better solution ...

 

[G.Patton]

You can try and share us by your result

 

[Mystery_chemistry]

well ... how to know that everything reacted and the reaction is over? I suggest copper chloride sink to the bottom… a good way out?

 

[G.Patton]

You can use Thin-layer chromatography (TLC) of drugs. Make two spots: one of reagent and one of product. Than, carry out TLC and check amount of p2np in product mixture. If there is no p2np in product mixture of spot very small, reaction is completed.

 

[chemutil]

If I understand correctly how P2NP is reduced to amphetamine, NaBH4 will reduce the -NO2 group and the alkene group. But I don’t understand what the role of CuCl2 is. Please explain how this mechanism works. Thank you in advance.

 

[G.Patton]

Hi. CuCl2 Works as catalyst in this reaction. Do you need more detailed explanation?

 

[Mystery_chemistry]

Hi, I wonder if the reductions can be made on the water only? after alkalisation, pour in a non-polar solvent and pull out the free base. it is possible ?

 

[WillD]

click. Steps 1-5 are better in waterless conditions (with one equivalent of NaBH4). After, with the resulting nitropropane and metal chloride as catalyst, water conditions are possible.

 

[MisterAnonymous]

@William Dampier what is the BP of Amphetamine Freebase and does it need to be distilled under vacuum?
Or does steam distillation also work?
I just want my Freebase colorless like water!

 

[KokosDreams]

What's the maximum liters of reaction mass you would load into your 100L glass reactor?

 

[mithyl2]

is this the correct cas number for the P2NP: 705-60-2

will any other cas numbers work?

 

[mithyl2]

and what % Sulfuric acid should be used?

 

[KokosDreams]

That is the correct CAS number, I would recommend you to stick to this one.

You can contact Constantylious777 from the forum, he's selling good quality P2NP, also there are other clearnet vendors that offer this product.

 

[mithyl2]

thanks for letting me know

 

[KokosDreams]

You are welcome!

 

[WinterDust]

Hi, have some questions about the synthesis.

6. 25% water solution of NaOH (8 liters) was added to reaction mixture and the phases were separated.

Q: You ad the NaOH to the synthesis and it splits into two laywers, and you drain the bottom layer and keep the upper layer?

7. The aqueous phase was there after extracted with 8 liters of IPA.

Q: I don't understand this part, after separation from step 6 you ad 8l of IPA and mix it?

8. IPA was evaporated on vacuum to an oil.

Q: Can I use a homemade small distiller to evaporate the IPA? And at what temperature should it be evaporated 60C?

9. The oil was dissolved in two liters of acetone.

Q: I don't understand this part, you ad the acetone to the oil and then start with the sulphuric acid step to get it into the right pH?

Bdst regards

 

[tucoXxX]

hi I am looking for answers to these questions. if you got it, can I see it? I'll go through the thread to see if I can find it.

 

[Curiousonion]

Isn't sodium borohydride expensive?
And at 3 kilos to produce 1 liter of amphetamine oil the cost would be a bit too much for it to be attractive.

 

[flyhigh]

good question.

 

[antrax]

Did you finally synthesize amphetamine sulfate (speed) following this route?