Syntheses of 2C-phenylethylamines

[NarwhalFucker419]

Does anyone have info on brominating 2C-H with n-bromosuccinimide? I've seen a few people mention it elsewhere but haven't found any writeups.

 

[Raxmil]

I'm looking for this too but I could not find the detailed information
What I know is you can do it in GAA or DCM but no idea about the ratio

 

[btcboss2022]

I have a doubt over the last step of 2CB synth. It says "The reaction mixture was allowed to return to room temperature, filtered, and the solids washed sparingly with cold acetic acid" until I know acetic acid becomes solid at 16-17C so what means cold acetic acid exactly?
Thanks.

 

[G.Patton]

Hi. I'm assuming that the cold acid means room temperature because there is an explanation that the reaction releases heat.

 

[btcboss2022]

Ok ok I thought that too but I preferred to confirm as you know when we say cold normally we means from freezer not RT hahaha but with acetic acid is not possible ;-) thanks

 

[w2x3f5]

I don’t quite understand why washing amine hydrobromide, it’s impossible to use it, it burns. It is better to purify and get the hydrochloride and the losses are less, as to avoid dubious attempts to wash the powder from bromine.

 

[nujrc]

I understand that remaining elemental bromine is going to evaporate in the air from product, just like any solvent, so there won't be any reasonable amount left with time. Making HCL without drying HBr - good luck to get more pure product, because you may have to deal with bromine salts in bromine/GAA solution, and bromine itself.

 

[w2x3f5]

I don’t see any problems to beat the remains of bromine with thiosulfate, then bring the ph to an alkaline medium and collect the oil with a solvent.

 

[situ1984]

(R)-(+)-α-methylbenzylamine CAS number:
3886-69-9 Is it from the lungs? Or is it absorbed by the stomach? Can it be used directly?
(R)-(+)-α-methylbenzylamine CAS number:
3886-69-9 Is it from the lungs? Or is it absorbed by the stomach? Can it be used directly?

 

[G.Patton]

It has no psycho-effects.

 

[amieri]

Where does one get 2,5 dimethynitrostyrene

 

[HerrHaber]

Henry condensation of 2,5-dimethoxybenzaldehyde with nitromethane in presence of a primary amine as catalyst.