Synthesis of Amphetamine from P2NP via SnCl2 and Zn

[mithyl2]

depending on where you are in the world you can buy reagent test kits.

google 'reagent test kits'.

and do you mean, is snorting a good way to test the product?

 

[TucoSalamanca.]

Should the product be a/b extracted again after a/b extraction?

 

[TucoSalamanca.]

When I prepare 38 hcl acid, do I cool it or add it directly?

 

[TucoSalamanca.]

If I add the aqueous acid slowly, the solution still turns white.

 

[mithyl2]

You add it to an already cooled amount of water (the method says: 'Place 150 ml of cold water and 4 ml 36% hydrochloric acid in a glass'). So yes, you add the hcl solution cool.

Have you tried any other method to synthesize amphetamine?

 

[TucoSalamanca.]

I ask if there is cooling at room temperature

 

[TucoSalamanca.]

how many minutes do you recommend to add because when I add the reaction solution turns white

 

[mithyl2]

Yes I think I had the same thing happen - when I added the naoh solution after I added the hcl solution I got white precipitate, but this is apparently normal as per the guide.

 

[TucoSalamanca.]

I don't understand, I do the whole synthesis as it says, but the synthesis doesn't disappear, I always fail, I go crazy, I'm going to kill myself.

 

[TucoSalamanca.]

I lost 90gr p2np because of this synthesis

 

[mithyl2]

Yes! This is exactly my situation too! I'm doing everything as described in the methods with this synthesis and others but none of them work

 

[wael gano]

You can re-extract the basic acid of this salt that you obtained
Dissolve this salt in cold water, the ratio of water to salt is 1/1
Add 25% sodium hydroxide solution dropwise to pH12
You will notice an oily layer on top
Add the DCM solvent, mix it well, then throw it into the separating funnel and separate the DCM layers. The bottom extract it and keep it
Make a solution of 1 ml sulfuric acid and 10 ml acetone or isopropyl alcohol
Add a drop of sulfuric acid solution and a precipitate of amphetamine salts will form
Adjust pH6
Keep it in the freezer for two hours
Then take it out and put it on a filter to dry

 

[mithyl2]

But if there's no amphetamine present in the salt, there won't be any oily layer (i think this is the amphetamine free base) forming on top, right? Tuco's problem seems to be the same as mine, where we are not synthesizing amphetamine, but another unidentified compound. I have repeatedly experienced this failure with the borohydride method as well, even when I used different forms of it

 

[wael gano]

Yes, correct
If a transparent or slightly yellowish oil layer does not form in the separating funnel, it is important to see an oil layer when extracting the base.
If you don't see this, you won't have a free amphetamine base (maybe you reacted wrongly).
There is a concern about the tin chloride process and the extraction of the oxime in ethyl acetate. When extracting the oxime in ethyl acetate does delamination occur? Can you extract the oxime in a non-polar solvent, ether or DCM?
There is an interference of inorganic salts in this synthesis

 

[wael gano]

Borohydride is a good reducing agent
Make sure it is pure copper chloride
I suggest you react p2np with aluminum amalgam. Try it in small quantities, starting with the correct amalgam. Add p2np in two stages and control the temperature of the amalgam.
Extract the free base with isopropyl alcohol

 

[TucoSalamanca.]

Can you write in detail how many ml dcm 2gr p2np calculation instead of ethyl acetate?

 

[Shulgin69]

Hi,
how does the oxime actually look like in pure form ? And which solvent to use, to recrystallize it ?
Best regards

 

[TucoSalamanca.]

1gr p2np
3.5ml acetone
2.94gr tin registered
10ml cold water 0.28ml hcl
14ml h2o 14gr no
3.5ml dcm
4.2ml glacial acetic acid
0.7gr
7ml h2o 3.5gr no
3.5ml dcm 3x1.4ml dcm
3.5ml acetone desired acid
I'll do this in my synth tomorrow. There are rumors that ethyl acetate does not oxidize, let's see if this will happen with DCM.

 

[sandman]

I don't think this works. I hope it does and will have to try it.

 

[TucoSalamanca.]

I hope you succeed, mate, I failed.

 

[mithyl2]

have you tried the method using borohydride?

 

[TucoSalamanca.]

I tried and failed, this method is better, I will use dcm instead of ethyl acetate, I hope it will work

 

[mithyl2]

I've done the borohydride method many times with no success. the closest i came was making about 0.2% yield of amphetamine. it was real though. i need this to work very badly, and it's driving me absolutely mad. let us know how the dcm goes.

 

[TucoSalamanca.]

I will write, my friend, do not miss your prayers so that this synthesis can be realised, thank you.