Ephedrine by Akabori Momotani ˇN-methylalanineˇ,Did you succeed?

[Pajmon]

Hi please, has anyone tried this reaction? I do, and I have a few questions.

Thanks

 

[rampage]

i'm pretty sure it's been tried but the yield was too low to make it worth it.

 

[Eleusius_hive_reboot]

yes i did back in 2014...
*I RECOMMEND NOT WASTING
TIME AND REAGENTS ON THAT *

about 35% - 40% yield, based on 1mol-Benzaldehyde
Reaction carried out in xylene as reaction-medium+anhydrous acetic acid decarboxylation mechanics. | water was removed with a dean stark apparatus set up.....

the variant to obtain Norephedrine,
went even more wrong several times.
but i somehow managed to drive the outcome in the desired products direction, i 've forgotton what adjustment i made...but if you are interested i dig out my lab notes in my paper-archive... that being said, ii never got even 20% PPA (Norephe...)

BUT....

while i am actively try to remember myself back in these
Times...
There is a bell ringing, in the Back of my "expanded-Consciousness"

I closed the Investigative research on condensing essential oils in one-pot with substituted Amino-Acids

BY:

A Novel Variant of
"The Azlactone Route"

(hybridizing the akabori momontani with
parts from the L-PAC/pyruvic-Acid / Azlactone Methods..)

article/step by step guide coming the next few days, in the synthesis section of amphetamine precursors....

 

[Pajmon]

I think the amount was fine, for me the problem was cleaning