4-MMC (mephedrone) synthesis. Bromination in dichlormethane.

[breathing.fire]

Anybody try do this with methylamine 33% in methanol?

 

[Marvin "Popcorn" Sutton]

Yes it works.

 

[euphoria84]

I found this on a Russian forum, according to them, 100% Bromoketone reacts in 7 hours at 30 degrees Celsius

 

[w2x3f5]

Author Linx (banned) the information is not reliable. The reaction in dichloromethane takes an average of 2 hours at 30 degrees.

 

[breathing.fire]

If I don't have acetone or IPA I can replacement them with other alcohol like methanol or ethanol?

 

[Marvin "Popcorn" Sutton]

The alcohols have to be of good quality to fit. IPA is the most readily available. Methyl and ethyl should also work, but they are harder to find the right quality.

 

[karate.kid]

I hear people after amination wash with water later NaOH this is necessery?

 

[Razel]

No

 

[Marvin "Popcorn" Sutton]

This method exists and has supporters. It is supposed to make the free base cleaner.

 

[w2x3f5]

Alkali can be used during amination to release methylamine from methylamine hydrobromide, it is important to use alkali in a deficient state.
This will give you methylamine savings.
Alkali contributes to the occurrence of side reactions, it should not be in a free form in the reaction.

 

[karate.kid]

I can replace acetone or ethyl acetate IPA?

 

[Razel]

Yes u can

 

[Marvin "Popcorn" Sutton]

IPA is not suitable for washing dirty powder, only for acidification or recrystallization.

 

[karate.kid]

Why?This take little staff if I want clean with this ?

 

[casperghost]

How minimal acetone must be when I give HCl?Is better give little to base or mix HCl with acetone

 

[mocnykutas]

?

 

[G.Patton]

First of all, hello! 1:1 to 1:4 (HCl:acetone). Add acetone into the acid sln.

 

[SonicNL]

How long does it take to dissolve 2-Bromo-4'-methylpropiophenone in DCM?

 

[mocnykutas]

No so long 5min

 

[SonicNL]

When working with 2 bromo 4 methylproiophenone you could dissolve 1 : 3 with DCM and start methylamation with 40%, or am I overlooking things here?

Also it also appears to me that the opinions are divided regarding the temperature on which the methylamation takes place. I read that 32-36 C and the solotion is stirred for 2 - 4 hour.

 

[mocnykutas]

Made and show as its true or no simple

 

[mocnykutas]

This how must look.
Have good work

 

[SonicNL]

Nice clear yellowish solution you have there. At what point of the synthesis is this picture taken?

 

[mocnykutas]

Made safe