JWH-018 synthesis

WillD

Expert
Joined
Jul 19, 2021
Messages
774
Reaction score
1,054
Points
93
No video, but I can advise in detail on the process here, private message or XMPP. I have enough practical experience on this synthesis.
 
View previous replies…

WillD

Expert
Joined
Jul 19, 2021
Messages
774
Reaction score
1,054
Points
93
No, time does not decrease. We cannot use nitromethane, we get a product, but the yield will be lowered, and it will be more difficult to clean. Maybe you can buy 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)? Although its price does not allow being the best option.
 
Last edited by a moderator:

French chocolate

Don't buy from me
New Member
Joined
Jan 17, 2022
Messages
5
Reaction score
3
Points
3
Does anyone have access to this noid ?
 

Marc-BenzoScam

Don't buy from me
Resident
Joined
Mar 1, 2023
Messages
8
Reaction score
3
Points
3
That's the million dollar question Frenchie. I guess I'm below a noob because I'm definitely not a chemist but I can move some shit.
 

WillD

Expert
Joined
Jul 19, 2021
Messages
774
Reaction score
1,054
Points
93
Where it is written about cooling, yes, the reaction is exothermic. Add reagents very neat and slow
 

Khaled

Don't buy from me
Resident
Joined
Dec 23, 2022
Messages
8
Reaction score
4
Points
3
What is an alternative to Tin (IV) chloride?
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,704
Solutions
3
Reaction score
2,849
Points
113
Deals
1
Probably yes, because Hexane and DCM are miscible solvents. Take into account that you have to count volume of SnCl4 in hexane in according with concentration to add equal amount SnCl4 as in this manual.
 

Khaled

Don't buy from me
Resident
Joined
Dec 23, 2022
Messages
8
Reaction score
4
Points
3
What is an alternative to Tin (IV) chloride?
 

curiousbob221

Don't buy from me
Member
Joined
Oct 10, 2022
Messages
6
Reaction score
0
Points
1
Hi, we ordered the 109555-87-5 direct from supplier, but they sent 83-34-1.....3-methylindole.
Could this product replace the 109555-87-5 in this synthesis?
If not is there another route using the 83-34-1 or is this product no good.
Help appriechated.
 

HerrHaber

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 15, 2023
Messages
565
Reaction score
303
Points
63
Sorry mate the suppliers seem to be mocking you 3-methyl indole is also known as skatole and it is the litteral smell of shit (I'm afraid I'm not joking) and unfortunately it can't be used for the preparation because the 3 position is occupied by methyl (did not say it is impossible since oxidation of the methyl to carboxylic acid which in turn could theoretically rather than in practice be converted to the acyl chloride to further Friedel-Crafts it with naphtalene is just my imagination and never heard of anyone doing this) Best advice is buy indole since it's probably the cheapest building block in the whole molecule.
 

abbadon

Don't buy from me
Resident
Language
🇺🇸
Joined
May 4, 2022
Messages
52
Reaction score
13
Points
8
hi friends, i want ask, the ones with success in JWH-018 synthesis:
is anyone located in europe and able, to sell maybe a small amount or more of the finished product?
pm please
 

jarmy

Don't buy from me
Resident
Joined
Oct 25, 2022
Messages
12
Reaction score
2
Points
3
Please help about Tin (IV) chloride, I could not get it, and I found Tin (Il) chloride in a solid state, not a liquid, so can I use it in the reaction
 

HerrHaber

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 15, 2023
Messages
565
Reaction score
303
Points
63
SnCl2 (stannous chloride) is not a strong Lwis acid that is needed to catalize the acylation reaction; you can find a preparation on youtube where the target compound is tin triblutyl hydride but SnCl4 is prepared as an intermediate from Sn metal powder in a heated tube thru which Cl2 is passed. This is hardcore chemistry so it shouldn't be attempted by amateurs not that jwh018 is
 

jarmy

Don't buy from me
Resident
Joined
Oct 25, 2022
Messages
12
Reaction score
2
Points
3
Thank you for your interest and reply. Is there another alternative to it and what it is
 

madmoney69

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 29, 2022
Messages
165
Reaction score
159
Points
43
I have tin 4chloride.
europe only
 

jarmy

Don't buy from me
Resident
Joined
Oct 25, 2022
Messages
12
Reaction score
2
Points
3
Thank you very much
 

jarmy

Don't buy from me
Resident
Joined
Oct 25, 2022
Messages
12
Reaction score
2
Points
3
In the second and final step, I fixed the temperature at 70 degrees Celsius, and in the end the product came out weak. Accordingly, what is the temperature required for the reaction in the last stage?
 

Rita

Don't buy from me
Resident
Joined
Feb 24, 2023
Messages
8
Reaction score
2
Points
3
Jwh is for beginners. For the old people, it is weak but active:)
 

charmingcho

Don't buy from me
Resident
Joined
Oct 17, 2022
Messages
20
Reaction score
3
Points
3
In the first step, I succeeded in obtaining it in solid form. And I tried to recrystallize it with ethanol, but it didn't get well, so I recrystallized it with IPA. And the second step is the reaction I tried to recrystalization with ipa without solidifying it properly because I was in a hurry. But it was not obtained in a solid state. Do I have to do something solid when recrystallizing? And what is the most suitable recrystallization solvent in step 2?
 

madmoney69

Don't buy from me
Resident
Language
🇬🇧
Joined
Jan 29, 2022
Messages
165
Reaction score
159
Points
43
FjvYr8nOhI
 
Top