Hey guys, i have bought these:
Can i extract pseudoephedrine from them and if yes how?
Nurofen Cold & Flu 200mg Film-Coated Tablets
Contain a pain reliever and decongestant to tackle cold and flu symptoms. Find out product details, dosage information and where to find it.
www.nurofen.ie
Can i extract pseudoephedrine from them and if yes how?
- Language
- 🇺🇸
- Joined
- Nov 16, 2023
- Messages
- 227
- Reaction score
- 162
- Points
- 43
So you have ibuprofen and pseudo HCl in your pills. Also, whatever the inactive ingredients are, but it's not so important. Pseudoephedrine is not very soluable in acetone.
Ibuprofen is soluable in acetone. Most likely, so is the coating on the pills, and perhaps (hopefully) some of the inactive ingredients. So if there is a color coating, wash it off with cold dry acetone. After you get it off, then crush the pills and dissolve everything into cold dry acetone again. Keep the solids, this is your PSE, get rid of the liquid. Repeat this atleast 3 times. Try to only use just enough acetone to do the job and no extra. Make sure it is cold as you can get it and dry with a dessicant (Mg2SO4) - No moisture! Otherwise you are just wasting your PSE.
After you washed with acetone and you have your solids, now dissolve the solids in dry methanol. PSE is very soluable in methanol. Ibuprofen and the color coating is also, but we got rid of them with the acetone already. So the only other thing with our PSE in the methanol is whatever inactive ingredients that are soluable in methanol that the acetone didn't wash away. If you are doing a SNB, these trace inactives probably won't matter because the SNB reaction is 'dry' - there is little to no H2O, however, if you are doing a RP cook, you may want to check your inactive ingredients and their soluability properties and try to remove them if you need to. You will want to perform this BEFORE you dissolve your solids in methanol. If the only ingredient left with your solids that is soluable in methanol is your PSE, then you don't need to worry. Pour your methanol in an evaporation dish and let it evaporate. Wash your solids with methanol atleast 3 times, filter it very well and combine all of the methanol and let it evaporate. It will crystalize in your dish and you can scrape up some pretty decent grade PSE for experimentation. You should be good to go forward with your PSE at this point.
Good luck, take care.
Ibuprofen is soluable in acetone. Most likely, so is the coating on the pills, and perhaps (hopefully) some of the inactive ingredients. So if there is a color coating, wash it off with cold dry acetone. After you get it off, then crush the pills and dissolve everything into cold dry acetone again. Keep the solids, this is your PSE, get rid of the liquid. Repeat this atleast 3 times. Try to only use just enough acetone to do the job and no extra. Make sure it is cold as you can get it and dry with a dessicant (Mg2SO4) - No moisture! Otherwise you are just wasting your PSE.
After you washed with acetone and you have your solids, now dissolve the solids in dry methanol. PSE is very soluable in methanol. Ibuprofen and the color coating is also, but we got rid of them with the acetone already. So the only other thing with our PSE in the methanol is whatever inactive ingredients that are soluable in methanol that the acetone didn't wash away. If you are doing a SNB, these trace inactives probably won't matter because the SNB reaction is 'dry' - there is little to no H2O, however, if you are doing a RP cook, you may want to check your inactive ingredients and their soluability properties and try to remove them if you need to. You will want to perform this BEFORE you dissolve your solids in methanol. If the only ingredient left with your solids that is soluable in methanol is your PSE, then you don't need to worry. Pour your methanol in an evaporation dish and let it evaporate. Wash your solids with methanol atleast 3 times, filter it very well and combine all of the methanol and let it evaporate. It will crystalize in your dish and you can scrape up some pretty decent grade PSE for experimentation. You should be good to go forward with your PSE at this point.
Good luck, take care.