p2np nabh4 síntesis de anfetaminas pregunta

[SoldadoDeDrogas]

Tuco amigo mío,
He mirado la receta del sintetizador de una olla y la solución CuCl2/H2O está en proporción 1/2, lo que significa que para 200mg de CuCl2 usarías 400mg de H2O como proporción de la solución.
La temperatura no aumenta tal vez porque es una escala tan pequeña. Además, estás utilizando un matraz de dos litros, un poco grande para lo que estás trabajando, ¿no?
Después de añadir la solución de CuCl2, la temperatura se mantiene a 80c durante 30 minutos con ayuda de un calentamiento externo. ¿Tienes una placa calefactora que puedas conectar?
Añade tu solución de NaOH a la base. Separa la fase acuosa utilizando IPA y reduce de nuevo a freebase con un vacío.
Disuelve la base libre en acetona y añade H2SO4 hasta pH 6.
Colocar en el congelador durante ~12 horas
Recoger la sal y lavar con acetona fría y seca hasta que quede de color blanco.

Si usted todavía está teniendo problemas con estas porciones yo sugeriría el uso de un lote más grande. Ese es un hilo de 45 páginas, y no es el único. Tiene que haber más info ahí que te pueda servir. Lee hermano.

 

[TucoSalamanca.]

Les explico como hacerlo, primero agregare 10ml de ipa 80ml de h2o, luego agregare 3.5gr de nabh4, luego agregare 2gr de p2np, no sobrepasando los 60 grados, luego disolveré cloruro de cobre 456mg en 1ml de agua y lo agregare, no sobrepasando los 80 grados, luego lo calentare a 80 grados por 30 minutos, tomare la capa superior y agregare la solucion con 16ml de agua 25% de naoh, luego hare ph 6 y lo pondre en el congelador.

 

[SoldadoDeDrogas]

Tras el freebasing con la solución de NaOH. Añadirá IPA para disolver el freebase en la capa de agua. Separa la capa de agua y evapora para recuperar el freebase.
A continuación, añada el freebase a la acetona y añada H2SO4 hasta que tenga un pH de 6. A continuación, colóquelo en el congelador. Se formarán sólidos y se filtrarán. Lavar los sólidos con acetona fría y seca hasta que adquieran un color blanco.

 

[Chemdogkm]

Smalllllll scale. Had good success with nabh4 synth at p2np 10g scale,but yield was only 20%

 

[GhostChemist]

yield in AMP synthesis (P2NP+NaBH4) must be 60-70%
http://bbzzzsvqcrqtki6umym6itiixfhn...esis-from-p2np-with-nabh4-cucl2-1kg-scale.70/

 

[OneTensionSkyRed]

I have some interesting information on NaBH4/Cu reduction of nitropropenes. Some say that this reaction produces hydroxylamine as the main product or even as the only product. The reason is that nitropropenes are harder to reduce unlike nitrostyrenes. So NaBH4/Cu gives phenylethylamine when reducing phenyl-2-nitrostyrene but with p2np it gives N-OH instead of amine - or at least a large part of the product is N-OH with some part as amine. The problem is that amphetamine and it's hydroxylamine have very similar boiling points and melting points for their salts and they're hard to separate and analyse.
People are saying that p2np reduced by amalgam and the same p2np reduced by NaBH4/Cu have very distinct effects for users.
Can anyone confirm or debunk this? Has anyone tried analysing the product by TLC?

 

[waltjr5858]

Agreed but only the way most people run it... it will make full ampehtamine but the size and shape of the catalyst is extremely important for it to really work. Otherwise stuck with that intermediate. If the copper is just dumped into an unknown quantity of nabh4 in solution yes hydroxylamine will most likely be the product....call it almost ampehtamine. Best way is to use thf and methanol 10:1 and get the 1-phenyl-2-nitropropane intermediate with no addition reaction this way. Then destroy remaining nabh4 and isolate propane. Dissolve in the normal 2:1 isopropanol water and now we will be using a set amount of nabh4 to make proper cu nanoparticles which will absolutely reduce fully. A little finely ground carbon will also raise catalyst activity greatly. Use ratio of 1:2:0.15 for each mole of propane use 2 moles of nabh4 and 0.15 copper with about the same activated carbon. So little bits and your catalyst should start as brownish color. With the catalyst it is just increasing surface area and absorbing hydrogen and the meditates an electron transfer.... 30 mins 80c... boom fully reduced. I would practice on solvent volume to get that brown to brown red catalyst color. Without complicated equipment that's the only way I can tell the catalyst will function the way i want. I have it written down somewhere how much alcohol and water to use per gram of nabh4... that's what really matters. Don't want the copper reduced all the way immediately and inactive. I'll look.