p2np nabh4 amfetamīna sintēzes jautājums

[SoldadoDeDrogas]

Tu esi mans draugs,
Es apskatīju viena katla sintēzes recepti, un CuCl2/H2O šķīdums ir 1/2 proporcijā, kas nozīmē, ka 200 mg CuCl2 jūs izmantotu 400 mg H2O kā šķīduma proporciju.
Temperatūra nepalielinās, iespējams, tāpēc, ka tas ir tik mazs mērogs. Turklāt jūs izmantojat divu litru kolbu - tā ir diezgan liela, lai ar to strādātu, vai ne?
Pēc CuCl2 šķīduma pievienošanas temperatūru 30 minūtes uztur 80 °C temperatūrā, izmantojot ārējo sildīšanu. Vai jums ir karstā plīts, ko varat uzņemt?
Pievienojiet NaOH šķīdumu bāzei. Atdaliet ūdens fāzi, izmantojot IPA, un reducējiet atpakaļ brīvajā bāzē, izmantojot vakuumu.
Izšķīdina frībāzi acetonā un pievieno H2SO4 līdz pH 6.
Ievietot saldētavā uz ~12 stundām.
Savāc sāli un mazgā ar aukstu sausu acetonu, līdz tā iegūst baltu krāsu.

Ja jums joprojām ir problēmas ar šīm porcijām, es ieteiktu izmantot lielāku partiju. Tas ir 45 lappušu biezs pavediens, un tas nav vienīgais. Tur ir jābūt vairāk informācijas, ko jūs varat izmantot. Lasi, brāli.

 

[TucoSalamanca.]

Pastāstīšu, kā to darīt, vispirms es pievienoju 10ml ipa 80ml h2o, tad pievienoju 3,5gr nabh4, tad pievienoju 2gr p2np, nepārsniedzot 60 grādus, tad izšķīdu vara hlorīdu 456mg 1ml ūdens un pievienoju, nepārsniedzot 80 grādus, tad 30 minūtes karsēju līdz 80 grādiem, paņemu virsējo slāni un pievienoju šķīdumu ar 16ml ūdens 25% naoh, tad izveidoju ph 6 un ievietoju saldētavā.

 

[SoldadoDeDrogas]

Pēc atbrīvošanas ar NaOH šķīdumu. Jūs pievienosiet IPA, lai izšķīdinātu frībāzi ūdens slānī. Atdaliet ūdens slāni un iztvaicējiet, lai iegūtu atpakaļ frībāzi.
Pēc tam pievienojiet frībāzi acetonam un pievienojiet H2SO4 līdz pH 6 - tad varat ievietot saldētavā. Izveidosies cietvielas, un jūs filtrēsiet. Cietās vielas mazgā ar aukstu, sausu acetonu, līdz iegūst baltu krāsu.

 

[Chemdogkm]

Smalllllll scale. Had good success with nabh4 synth at p2np 10g scale,but yield was only 20%

 

[GhostChemist]

yield in AMP synthesis (P2NP+NaBH4) must be 60-70%
http://bbzzzsvqcrqtki6umym6itiixfhn...esis-from-p2np-with-nabh4-cucl2-1kg-scale.70/

 

[OneTensionSkyRed]

I have some interesting information on NaBH4/Cu reduction of nitropropenes. Some say that this reaction produces hydroxylamine as the main product or even as the only product. The reason is that nitropropenes are harder to reduce unlike nitrostyrenes. So NaBH4/Cu gives phenylethylamine when reducing phenyl-2-nitrostyrene but with p2np it gives N-OH instead of amine - or at least a large part of the product is N-OH with some part as amine. The problem is that amphetamine and it's hydroxylamine have very similar boiling points and melting points for their salts and they're hard to separate and analyse.
People are saying that p2np reduced by amalgam and the same p2np reduced by NaBH4/Cu have very distinct effects for users.
Can anyone confirm or debunk this? Has anyone tried analysing the product by TLC?

 

[waltjr5858]

Agreed but only the way most people run it... it will make full ampehtamine but the size and shape of the catalyst is extremely important for it to really work. Otherwise stuck with that intermediate. If the copper is just dumped into an unknown quantity of nabh4 in solution yes hydroxylamine will most likely be the product....call it almost ampehtamine. Best way is to use thf and methanol 10:1 and get the 1-phenyl-2-nitropropane intermediate with no addition reaction this way. Then destroy remaining nabh4 and isolate propane. Dissolve in the normal 2:1 isopropanol water and now we will be using a set amount of nabh4 to make proper cu nanoparticles which will absolutely reduce fully. A little finely ground carbon will also raise catalyst activity greatly. Use ratio of 1:2:0.15 for each mole of propane use 2 moles of nabh4 and 0.15 copper with about the same activated carbon. So little bits and your catalyst should start as brownish color. With the catalyst it is just increasing surface area and absorbing hydrogen and the meditates an electron transfer.... 30 mins 80c... boom fully reduced. I would practice on solvent volume to get that brown to brown red catalyst color. Without complicated equipment that's the only way I can tell the catalyst will function the way i want. I have it written down somewhere how much alcohol and water to use per gram of nabh4... that's what really matters. Don't want the copper reduced all the way immediately and inactive. I'll look.