JWH-018 synthesis
1-4 . The reaction mixture is quenched with ice water 20 L, extracted with ethyl acetate 15 L and filtered to remove inorganic precipitates on a nutsche filter.
Does this process use a separation funnel the water from the organic layer?
Does this process use a separation funnel the water from the organic layer?
Hi, we ordered the 109555-87-5 direct from supplier, but they sent 83-34-1.....3-methylindole.
Could this product replace the 109555-87-5 in this synthesis?
If not is there another route using the 83-34-1 or is this product no good.
Help appriechated.
Could this product replace the 109555-87-5 in this synthesis?
If not is there another route using the 83-34-1 or is this product no good.
Help appriechated.
- By HerrHaber
Sorry mate the suppliers seem to be mocking you 3-methyl indole is also known as skatole and it is the litteral smell of shit (I'm afraid I'm not joking) and unfortunately it can't be used for the preparation because the 3 position is occupied by methyl (did not say it is impossible since oxidation of the methyl to carboxylic acid which in turn could theoretically rather than in practice be converted to the acyl chloride to further Friedel-Crafts it with naphtalene is just my imagination and never heard of anyone doing this) Best advice is buy indole since it's probably the cheapest building block in the whole molecule.
I didn't. It is quite usual problem of organic synthesis. Many organic reactions give oily product, which is have to be crystalized. You have to apply some chemical tricks in order to get crystalline product. Sometimes flash chromatography is only one way. Sometimes you need just find appropriate crystallization solvent.