Síntese da dextroanfetamina (Nabenhauer, 1942)

[Chemdogkm]

what is the purpose of adding nickel chloride hydrate to this reaction ? A second catalyst?how does it work and should it be used?

 

[G.Patton]

It is not necessary.

 

[Chemdogkm]

is it a substitute for aluminum?

 

[Chemdogkm]

can it be used and how so? I see it is mentoined in multiple synths

 

[Chemdogkm]

sorry to bother,im sure playing 20 questions gets old

 

[Rabidreject]

As for MDA synth, I hate to disappoint but I bought the md-p2np already made - I don’t like the group of drugs enough to bother doing the Henry reaction etc but seeing as I saw it for sale, I reduced some over the previous couple days (via NaBH4 catalysed by copper - although from my understanding there are many ways to reduce nitroalkene’s) and now I have a bunch of r-MDA.
Now I will follow the latter part of the synthesis from where you have your r-amphetamine.
I can’t say I have ever seen 3,4-MDbenzaldehyde for sale…I take it that is the same as piperonal?

 

[Eleusius_hive_reboot]

hey patton !


i HATE Hg-Salts......

(who doesnt ?) I MANAGED TO SUBSTITUTE THE AGENT; to break the oxide layer, by catalyst poisoning,


YOU CAN USE SEVERAL OTHERS LIKE:

1. Gallinstan (known in newer lit. already, but a bit trickyer...)

2. Tetrachloroaurate with zinc-copper coupling complex.

===== BUT NOW, LADIES AND GERMS ============

PRE TREAT THE ALUMINUM CUTTINGS WITH ULTRA SONICATION BATH

(CREDITS TO ARTIFFICCIAL INTELLIGENCE FOR SCIENTIFIC PURPOSES)

this f**king DID THE JOB !!!!!


tried it for p2p -> imine reduction......its comparable to my former NaBH4 dreams...!