Sinteza amfetamina iz P2NP z NaBH4/CuCl2 v enem loncu (merilo 1 kg)

Montecristo

Don't buy from me
New Member
Joined
Dec 29, 2021
Messages
102
Reaction score
37
Points
18
Tukaj je bilo tisto, kar sem naredil v manjšem obsegu;
1. Raztopini IPA/H2O 2:1 ((IPA 800ml, H2O 400ml)(1200ml)) sem dodal 2000ml bučko.
2. NaBH4 (116 g) smo dodali naenkrat in začeli mešati.
3. P2NP (67 g) je bil dodan v majhnih obrokih, tako da temperatura zmesi ni presegla 60 *С.
4. CuCl2 (7 g) v vodi (13 ml) je bil dodan počasi po kapljicah, tako da temperatura zmesi ni presegla 80 *С.
5. Nato smo reakcijo z zunanjim ogrevanjem 30 minut refluksirali pri 80 °C.
6. Raztopina se dekantira in filtrira od reakcijskih odpadkov ter prelije v separacijski lijak.
7. Reakcijski zmesi smo dodali 25-odstotno vodno raztopino NaOH (533 ml) in ločili faze.
8. Spodnjo plast odcedimo v veliko čašo in zberemo zgornjo organsko plast.
9. Vodno fazo smo nato prenesli v separacijski lijak in jo ekstrahirali s 500 ml IPA.
10. IPA je bil izparevan po 3/4, polovica mlečne proste baze in polovica IPA.
11.IPA in freebase smo raztopili v 130 ml acetona.
12.ortofosforna kislina je kapljala do pH - 6 (ob stalnem mešanju).
13.Mešanica je bila za 12 ur postavljena v zamrzovalnik.
14.Po kristalizaciji smo suspenzijo filtrirali in izpirali s suhim hladnim acetonom, dokler aceton ni čist.
15.Aceton iz izpiranja in zmes ipa/aceton smo dali nazaj v zamrzovalnik za nadaljnje obarjanje.
16. Postopek se ponovi, dokler ni več oborine, da dobimo 60-70 % visokokakovostnega amfetamina, ker je v mešanici več acetona, bo morda treba kapniti še nekaj kisline, da se zniža, vendar ne preveč, saj je aceton ph7.

Tukaj je fotografija nekaterih posušenih kamnov iz paste, ostalo je suh prah, ki ga je treba zmešati, saj je premočan zame in moje prijatelje.
Morda bom posodobil recept in napisal članek za male domače kemike, saj je veliko načinov, kako bi bilo to mogoče izboljšati.
 

Attachments

  • yrIiJuK8x7.PNG
    yrIiJuK8x7.PNG
    901.1 KB · Views: 553

flyhigh

Don't buy from me
Resident
Joined
Jul 2, 2023
Messages
17
Reaction score
8
Points
3
to ni metamfetamin , ali lahko od tu napišete, kako ga narediti za kristalni metamfetamin
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
A different process. P2P or sudo. Just pick one. But these are safer imo
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,749
Solutions
3
Reaction score
2,933
Points
113
Deals
1
Pozdravljeni. CuCl2 v tej reakciji deluje kot katalizator. Ali potrebujete podrobnejšo razlago?
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
I would like to know the entire concept if u k know it. Like how much copper to reduce p2np exactly. Are we making an electron here in this synth? What is going on exactly ? I understand how to run through but not the actual chemical reaction that is happening.
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,749
Solutions
3
Reaction score
2,933
Points
113
Deals
1
What do you mean?
There is clearly said how much. 105g CuCl2 per 1kg P2NP.

NaBH4 donate hydrogen while this reaction to P2NP and nitrogen atom change its oxidation state from +3 to -3. Hence, it get 6 electrons.
 

mithyl2

Don't buy from me
Resident
Language
🇬🇧
Joined
Aug 19, 2022
Messages
264
Reaction score
27
Points
28
in kolikšen % žveplove kisline je treba uporabiti?
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
Buy virgin sulfuric from as drain cleaner if u can’t find one with a high purity. I could only find like 20% online for some reason. The drain cleaner is actualy more pure. Like wtf
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,749
Solutions
3
Reaction score
2,933
Points
113
Deals
1
it's worth to use 96-98%, but you can use less concentrated as well.
 

diogenes

Don't buy from me
Resident
Language
🇬🇧
Joined
Dec 27, 2021
Messages
183
Reaction score
99
Points
28
Pozdravljeni,

pravkar sem opravil to sintezo in izkoristek je 60 %+ (nekaj acetona je še vedno v zamrzovalniku), kar ni slabo glede na to, da se je reakcijska masa na neki točki razlila (pregrela se je in se začela širiti). Hitro sem jo ohladil in nato za preostanek reakcije uporabljal povratni hladilnik (prvotni opis tega ne omenja). Po dodajanju dela P2NP se toplota poveča z nekaj zamude, kar je treba upoštevati, saj sem prehitro dodal še en del. Priročna je hladna kopel. Končni produkt je zelo učinkovit v smislu biološkega testa, izvajam kislinsko-bazično ekstrakcijo, da vidim, ali so v končnem produktu tudi druge kemikalije. Obstaja rahel, izrazit vonj, ki je po mojem mnenju blizu vonju Cu, ki ostaja kljub 5-kratnemu izpiranju z acetonom in zelo belemu, čistemu videzu izdelka.

Zanima me, ali je kdo, ki bi lahko natančno opisal reakcijo, ki se dogaja pri tej sintezi. Vloga CuCl2 mi ni jasna, prav tako mi ni jasno, kako se premikajo atomi H itd. Zelo koristno bi bilo, če bi bila reakcija malo bolj podrobno razložena. Opravičujem se, če je bilo to že omenjeno, videl sem večino te teme, vendar v zadnjem času nisem imel priložnosti dohiteti. Hvala.
 

mile123

Don't buy from me
Resident
Language
🇺🇸
Joined
Sep 18, 2024
Messages
6
Reaction score
1
Points
3
Hello!

What reflux condenser do you recommend, is Friedrichs really worth double the price compared to Graham?


I read here that @OrgUnikum recommends Friedrichs.


I'm thinking about adding reflux condenser at 3. step

because of suggestion below

and possible h2 production safety reasons


Br,
Mile
 

WinterDust

Don't buy from me
Resident
Joined
May 21, 2022
Messages
229
Reaction score
211
Points
43
Deals
3

Trenutno izdelujem serije po 200 g P2nP.

Imam precej dobro metodo hlajenja, tako da moja temperatura nikoli ne preseže 47 stopinj Celzija.

Za dodajanje celotne porcije 200 g je potrebna 1 ura.

Ko dodate P2nP, reakcija prvič traja nekaj časa in se začne peniti, med penjenjem. Ne dodajajte več P2nP! Počakajte, da se pena ustali in da vidite 60 % pene in 40 % tekočine, to je "mehka točka" za dodajanje drugega obroka.
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
What all am I looking for during the reaction, can u see when it is happening and when it is done ? Can u explain more about what the chemistry is behind what is happening during the reaction. Just to have more understanding of how it works
 

WinterDust

Don't buy from me
Resident
Joined
May 21, 2022
Messages
229
Reaction score
211
Points
43
Deals
3
Pozdravljeni,

Vprašanje,

Ko se amfetaminsko olje kristalizira z žveplovo kislino, je čas, da amfetamin filtriramo z Buchnerjevim lijakom, moje vprašanje je. Katera vrsta filtrirnega papirja je priporočljiva za to?

Iščem na primer filter z naslednjimi lastnostmi, ali je to dobro priporočilo?

Lastnosti filtra:
Filtrirni papirji iz tissue papirja
Trdi filtri - čas filtriranja 140 sekund (zadrževanje> 2 µm). Počasno filtriranje.
Gosti filtri za fine in zelo fine usedline.
Teža: 85 g/m2.
Debelina: 0,17 mm.
Čas filtriranja: 140 s.
Zadrževanje:> 2 µm.


Z največjim spoštovanjem
 

mile123

Don't buy from me
Resident
Language
🇺🇸
Joined
Sep 18, 2024
Messages
6
Reaction score
1
Points
3
1. Material:
Generally, tissue paper is not recommended for chemical filtration, especially in organic chemistry, as it may not provide the necessary chemical resistance and could introduce impurities.

3. Retention:
This retention level is suitable for filtering out larger particles, but if the amphetamine salt crystals are smaller than this size, they may pass through the filter. For crystallization processes, you typically want a filter paper that can retain smaller particles, ideally in the range of 1 µm or less.


4. Weight (85 g/m²) and Thickness (0.17 mm):
a relatively dense filter paper, which may be good for fine filtration but could also slow down the process. Thicker filter papers tend to have lower flow rates

Recommendations​

Quantitative Filter Paper:
Look for papers with a retention size of 1 µm or less, which would be more suitable for filtering fine crystals.


Buchner Funnel Filtration:
Whatman filter paper or similar brands that are specifically designed for vacuum filtration. These papers are available in various grades, including those with finer retention capabilities (e.g., Whatman Grade 1 or Grade 2).

src: chatgpt

Let me know if something is wrong
 

ASheSChem

Don't buy from me
Resident
Language
🇫🇷
Joined
Apr 10, 2022
Messages
300
Reaction score
169
Points
43
dobro vprašanje... tudi mene zanima..
dejansko uporabljam to
FzdjT09Rtc
4Bi1xnHSvJ


vendar ne vem, kaj je to lol

Videl sem veliko vrst filtrov "kvalitativnih" ali "kvantitativnih" in v vsaki kategoriji različica "počasi" "srednje" in "hitro"...
Katera je najboljša? :p
 

mile123

Don't buy from me
Resident
Language
🇺🇸
Joined
Sep 18, 2024
Messages
6
Reaction score
1
Points
3
Quantitative Filter Paper
Specification: 9.0 cm
The second image has a table with various specifications, likely describing different types of filter paper based on attributes like thickness, pore size, or filtration speed.

9ut4zHprkZ

from chatgpt
 

wannabewalter

Don't buy from me
New Member
Language
🇺🇸
Joined
Nov 8, 2024
Messages
1
Reaction score
0
Points
1
What is a purity of a final 60% - 70% yield? I found that there is such thing as amphetamine paste and amphetamine sulfate and sulfate is x2 in price. What is this final product (124.4g on video)?
 

aaduo04

Don't buy from me
Resident
Language
🇭🇺
Joined
Jan 6, 2024
Messages
7
Reaction score
2
Points
3
a videóban a végső mennyiség szulfát. A paszta konzisztenciája tömeg szerint 3x lehet, mert az oldószerek nem párologtak el. (javítsatok ki, ha tévedek).
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
Can I do a run of the synth with only 5g p2np ? To get a grip on it first.
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,749
Solutions
3
Reaction score
2,933
Points
113
Deals
1
You have to! Small scale batch is necessary to carry out several times before large one in order to understand this synthesis and remember it well.
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
Is 5g p2np okay or too small ? And is pressure required during reaction or just the constant heating ?
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,749
Solutions
3
Reaction score
2,933
Points
113
Deals
1
Yes, okay. Atmosphere pressure.
 

Kylemalone1297

Don't buy from me
Member
Language
🇺🇸
Joined
Oct 27, 2024
Messages
31
Reaction score
7
Points
8
Is the pressure required or will it do fine just running hot with no pressure? Do I need to hold as much pressure as possible ? I have a nice 1000ml heavy wall round bottom. So it will hold some, but if it isn’t needed I won’t worry about it.
 

Ironbender

Don't buy from me
Member
Language
🇩🇪
Joined
Oct 24, 2024
Messages
2
Reaction score
0
Points
1
I tried this synthesis on a small scale.
It failed completely. In the end I didn't even receive A-Oil.

This was my path:

p2np 10g

IPA/H2O (1:2) IPA 120ml/H2O 60ml (180ml)

NaBH4 17.4g

CuSO4.5H2O 7.9g in 20ml H2O

NaOH 25.6g in 80ml H2O

First water and then IPA were filled into the flask at room temperature and stirred.

NaBH4 was completely filled into the flask and stirred overhead.

p2np was added over a period of 30 min.
The temperature did not rise above 45 degrees.

When all P2NP was in the flask I increased the temperature to 55-58 degrees and refluxed for 40 minutes.

Then CuSO4.5H2O
dropped into the flask. Black copper immediately formed
Somehow the temperature didn't increase.

The RM was heated in a water bath to 78-80 degrees for 30 minutes.

The flask was left at room temperature for 1 hour.

There were 2 layers in the flask, black copper at the bottom. 'Amber cloudy at the top.

There was something slightly yellow in between that couldn't be dissolved.

Then 80 ml of 25% NaOH was added to the RM and a dark amber layer became visible.

It didn't smell like amphetamine base,
it smelled very flowery.
Nothing reminiscent of Amphetamine Oil.

Can someone explain what was wrong?
I followed the small scale instructions from this thread

p2np was from BM-chemistry
and looks very clean and bright.
It can't fail because of that.

I'm sorry for the bad English, hope you understand what I want to say.
 
Top