Dextroamphetamine Synthesis (Nabenhauer, 1942)

[Amphibian]

Palladium Catalyst Preparation (haven't tried it out)

 

[Evilcarrot2]

Wow than
Wow thanks exactly what I've been looking for

 

[G.Patton]

I don't think so.
Wikipedia said:
A solution of palladium chloride and hydrochloric acid is combined with aqueous suspension of activated carbon. The palladium(II) is then reduced by the addition of formaldehyde. Palladium loading is typically between 5% and 10%. Often the catalyst mixture is stored moist.

I've never prepared Pd/C by myself.

 

[diogenes]

When you switch the tartaric acid isomers, then everything is simply the other way round. The amph isomer which was in the organic phase will be in the water and the salt (water soluble) will be in the organic. I know some people use the L tartaric acid (despite more difficult to get) because then the D amphetamine will be in the water phase.

 

[PhantomFeatherSword]

Excuse the amateur question, but when I was reading about tartaric acid on Wikipedia, there was a line that confused me a bit:
When I read the above "dextro tartaric acid or L-(+)-tartaric acid", I kinda read it as "dextro tartaric acid AKA L-(+)-tartaric acid".
Which makes me wonder, if I'm trying to isolate the dextroamphetamine isomer, should I be buying the L-(+)-tartaric acid (like this)? Or the D-(-)-Tartaric Acid (like this)? Im really hoping it's the D-(-)-Tartaric Acid, because that's what I already have.

 

[G.Patton]

Hello, you can use both of them. I wrote the method for L-tartaric acid. Read comments above. Your question is already discussed several times.
Also, read this theme.

 

[Midget_Impinger]

@G.Patton - Is this optical resolution process using d-tartaric acid applicable to other amphetamines? Specifically 4-fluoroamphetamine, 4-fluoromethamphetamine and plain ol methamphetamine?

 

[G.Patton]

Hello, yes, it is.

 

[Re186]

How to separate the chiral isomers of methamphetamine?Can this amphetamine technique be applied to methamphetamine?

 

[UWe9o12jkied91d]

Yes, it is the same

 

[41Dxflatline]

I've always added GAA and sometimes used 80% acetic acid too but later today I'm going to try without acetic acid at all. What ratio of IPA:Water do you use in your P2NP solution?

 

[G.Patton]

Hello

 

[UWe9o12jkied91d]

I've heard people use half of GAA, i used full GAA equivalent and still went fine, both ways are fine

 

[41Dxflatline]

Seems to be going ok:

https://imgur.com/a/37WuR3e

 

[nsrnsr]

Extract with 5 ml of petroleum ether and warm the solution...
May I ask what does it mean to extract?

 

[G.Patton]

Extraction one substance from a solution with help of an appropriate solvent.
Extraction

 

[nsrnsr]

Is it okay to use ether? Thank you

 

[G.Patton]

Do you mean diethyl ether (Et2O)? Yes, of course.

 

[nsrnsr]

May I ask whether to add d-tartaric acid first or extract first? Thank you

 

[G.Patton]

Of course you need extract amph free base before. In opposite case the acid will reacts with alkali (NaOH or KOH).