HIGGS BOSSON
Expert
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- Jul 5, 2021
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Reagents used in video:
Equipment and glassware:
Video Description:
Same procedures are for following substances syntheses:
- 1.50 g 2,2,2,3,3-Tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole; CAS 895152-66-6);
- 2.32 g Sodium hydroxide (NaOH);
- 3.10 g Tetra-n-butylammonium bromide (TBAB, CAS 1643-19-2);
- 4.46 g 1-Bromopentane (amyl bromide; CAS 110-53-2);
- Distilled water;
Equipment and glassware:
- Flat bottom flask 2 L;
- Retort stand and clamp for securing apparatus;
- Magnetic stirrer with heating plate;
- Reflux condenser;
- Funnel;
- Syringe or Pasteur pipette;
- Beakers (600 mL x3, 100 mL x2);
- Vacuum source;
- Laboratory scale (0.1-200 g is suitable);
- Measuring cylinder 250 mL;
- Glass rod and spatula;
- Separatory funnel 1 L (optional);
- Buchner flask and funnel;
- Filter paper;
Video Description:
0:05-1:12 - Alkali solution preparation;
1:13-1:42 - TMCP-indole addition into reaction mixture;
1:43-2:08 - TBAB addition into reaction mixture;
2:09-2:32 - 1-Bromopentane addition into reaction mixture (Rm);
2:33-3:50 - Rm is stirred and heated with reflux;
3:53-4:20 - Water is added at room temperature to clean the product from impurities;
4:20-5:10 - Top layer, which is contained UR-144, is decanted. Then, the bottom layer is extracted with benzene or ether to increase the yield. Solvent from this stage have to be distilled off for further product purification. Following purification steps can be skipped and top layer can be used for smoking mixtures producing in according with theory yield.
5:11-5:55 - Crystallization of dirty UR-144.
5:56-7:10 - UR-144 recrystallization from isopropyl alcohol (IPA) for product purification.
7:15-8:00 - Crystallized and cooled alcohol solution of UR-144 is filtred on Buchner funnel and flask. Filtered crystalline product is washed on Buchner funnel with a pure cold IPA. Keep in mind that product losses are possible in case of poor crystallization and insufficient cooling.
1:13-1:42 - TMCP-indole addition into reaction mixture;
1:43-2:08 - TBAB addition into reaction mixture;
2:09-2:32 - 1-Bromopentane addition into reaction mixture (Rm);
2:33-3:50 - Rm is stirred and heated with reflux;
3:53-4:20 - Water is added at room temperature to clean the product from impurities;
4:20-5:10 - Top layer, which is contained UR-144, is decanted. Then, the bottom layer is extracted with benzene or ether to increase the yield. Solvent from this stage have to be distilled off for further product purification. Following purification steps can be skipped and top layer can be used for smoking mixtures producing in according with theory yield.
5:11-5:55 - Crystallization of dirty UR-144.
5:56-7:10 - UR-144 recrystallization from isopropyl alcohol (IPA) for product purification.
7:15-8:00 - Crystallized and cooled alcohol solution of UR-144 is filtred on Buchner funnel and flask. Filtered crystalline product is washed on Buchner funnel with a pure cold IPA. Keep in mind that product losses are possible in case of poor crystallization and insufficient cooling.
Same procedures are for following substances syntheses:
JWH-018 from 3-(1-Naphthoyl)indole and 1-Bromopentane,
AM-2201 from 3-(1-Naphthoyl)indole and 1-Bromo-5-fluoropentane,
JWH-122 from 4-Methyl-1-naphthyl-indole and 1-Bromopentane.
And many different synthetic cannabinoids. 1-Pentyl-1H-indole chemical structure is one of the main affect key factor on cannabinoid receptors (CB1 and CB2).
AM-2201 from 3-(1-Naphthoyl)indole and 1-Bromo-5-fluoropentane,
JWH-122 from 4-Methyl-1-naphthyl-indole and 1-Bromopentane.
And many different synthetic cannabinoids. 1-Pentyl-1H-indole chemical structure is one of the main affect key factor on cannabinoid receptors (CB1 and CB2).
Last edited by a moderator:
- Joined
- Dec 27, 2023
- Messages
- 5
- Reaction score
- 1
- Points
- 3
I would like to ask, after I get the final crystallized product, what should I add to make the product return to an oily state for smoking?