UR-144 synthesis from TMCP-indole (large scale). Complete video tutorial.

[HIGGS BOSSON]

Reagents used in video:

• 1.50 g 2,2,2,3,3-Tetramethylcyclopropyl(1H-indol-3-yl)methanone (TMCP-indole; CAS 895152-66-6);​
• 2.32 g Sodium hydroxide (NaOH);​
• 3.10 g Tetra-n-butylammonium bromide (TBAB, CAS 1643-19-2);​
• 4.46 g 1-Bromopentane (amyl bromide; CAS 110-53-2);​
• Distilled water;​

Equipment and glassware:

• Flat bottom flask 2 L;
• Retort stand and clamp for securing apparatus;
• Magnetic stirrer with heating plate;
• Reflux condenser;
• Funnel;
• Syringe or Pasteur pipette;
• Beakers (600 mL x3, 100 mL x2);
• Vacuum source;
• Laboratory scale (0.1-200 g is suitable);
• Measuring cylinder 250 mL;
• Glass rod and spatula;
• Separatory funnel 1 L (optional);
• Buchner flask and funnel;
• Filter paper;

Video Description:

0:05-1:12 - Alkali solution preparation;
1:13-1:42 - TMCP-indole addition into reaction mixture;
1:43-2:08 - TBAB addition into reaction mixture;
2:09-2:32 - 1-Bromopentane addition into reaction mixture (Rm);
2:33-3:50 - Rm is stirred and heated with reflux;
3:53-4:20 - Water is added at room temperature to clean the product from impurities;
4:20-5:10 - Top layer, which is contained UR-144, is decanted. Then, the bottom layer is extracted with benzene or ether to increase the yield. Solvent from this stage have to be distilled off for further product purification. Following purification steps can be skipped and top layer can be used for smoking mixtures producing in according with theory yield.
5:11-5:55 - Crystallization of dirty UR-144.
5:56-7:10 - UR-144 recrystallization from isopropyl alcohol (IPA) for product purification.
7:15-8:00 - Crystallized and cooled alcohol solution of UR-144 is filtred on Buchner funnel and flask. Filtered crystalline product is washed on Buchner funnel with a pure cold IPA. Keep in mind that product losses are possible in case of poor crystallization and insufficient cooling.​

Same procedures are for following substances syntheses:

JWH-018 from 3-(1-Naphthoyl)indole and 1-Bromopentane,
AM-2201 from 3-(1-Naphthoyl)indole and 1-Bromo-5-fluoropentane,
JWH-122 from 4-Methyl-1-naphthyl-indole and 1-Bromopentane.
And many different synthetic cannabinoids. 1-Pentyl-1H-indole chemical structure is one of the main affect key factor on cannabinoid receptors (CB1 and CB2).​

 

[joejoe354354]

I would like to ask, after I get the final crystallized product, what should I add to make the product return to an oily state for smoking?

 

[HIGGS BOSSON]

Unfortunately, we have no suppliers. You need to look in China or India for the main precursor, the rest of the reagents are easy to find.

 

[航哥1234758]

I can get 1 kg of 1-bromopentane for about 500 RMB in China but I may need to hold it

 

[chemistrydude]

Hello TMCP-indole didn't melted to liquid phase can someone explain?

 

[HIGGS BOSSON]

Yes, but the activity of this cannabinoid will be weaker.

 

[HIGGS BOSSON]

Explain in more detail, at what point did it not melt?

 

[chemistrydude]

I used not checked TMCP-indole(and it been just normal indole) so yup now i got real one.

 

[dnkr]

what does TMCP-indole smell like? Now I'm worried I didn't get real one.

The one I have smells kind of weird.. like old urine

 

[chemistrydude]

It might be skatole or indole that you can get from poop, the smell of skatole can variety from urine to poop.

 

[chemistrydude]

The real TMCP-indole smells like normal indole but it's way concentrated and if someone "smart" to scam you, you just need buy little sample and check, you need have indole and skatole, first you need to smell the skatole and test on smell TMCP-indole if it smells like skatole it's fake, when it smells like way concentrated indole then it's real, be careful mate.

 

[hockey34]

can the bromine or ether be replaced with something else when you extract the bottom layer at 4:20-5:10 in the video?

 

[Ukspice]

What is UR-144 strength like compared to
5cl and adbb?

What would be the the strongest from 1 to 3 ?

I know 5cl is strong how does ur-144 compare??

 

[pvp]

Can i replace 1-bromopentane with 5-bromo-1-pentene?

 

[spacevapourzScam]

can this method be used to create adb butinaca or pinaca

 

[阿卡Mario]

If I only have 25g of indole what proportion should I use?

 

[joejoe354354]

I would like to ask how to turn the product into oil for smoking?