Leuckartova aminácia 1-fenyl-2-propanónu (P2P) na amfetamín a metamfetamín. Smelá stupnica.

[Selassi]

Plavec dostal otázku týkajúcu sa iného variantu tejto metódy:

Po prvom kroku (var s mravčou kyselinou a formamidom) sa teraz namiesto refluxu s HCl opäť varí organická fáza s vodou a NaOH.

Môže mi niekto vysvetliť metriku tohto odlišného druhého kroku? Swim to nikdy takto nerobil, ale zdá sa, že to ušetrí veľa času na rozdiel od oldschoolovej metódy s refluxovaním HCl.

Aká sila žieraviny/vody a koľko sa jej do reaktora dodáva na 1 l produktu?
Ako dlho by sa mala táto reakčná zmes variť a pri akej teplote?

 

[waltjr5858]

You can do hydrolysis with a base or an acid...

 

[G.Patton]

Používate spätný chladič a digestor?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[waltjr5858]

Ok... but in general then what would happen to the resulting solution if spun up with 30% peroxide?

 

[TheNut22]

Svoje silnejšie peroxidy vodíka som vyrobil z 12% H2O2. Len som z neho opatrne odparil vodu.
O výpočty som požiadal asistenta AI-robota v oblasti chémie. Je dobrý vo výpočtoch, ale nečakajte, že dostanete správne odpovede
z halogenácií alebo podobne...

 

[loadingST]

Ešte som reakciu neskúšal, ale pri dobrej hydrolýze s KOH a potom s HCL by mala dať vysoký výťažok a obávam sa, že pri práci s h2o2 sa nevytvoria žiadne výbušné peroxidy a pri destilácii nevybuchnú

 

[William D.]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William D.]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking

 

[Pinkbay]

sir, In step 3, is heating required?

 

[rampage]

can you replace n-methylformamide with dimethylformamide?