1-fenil-2-propanon (P2P) Leuckartova aminizacija do amfetamina in metamfetamina. Smiselna lestvica.

[Selassi]

Plavalec je dobil vprašanje v zvezi z drugačno različico te metode:

Po prvem koraku (vrenju z mravljinčnikom in formamidom) zdaj organsko fazo namesto refluksa s HCl ponovno zavrejo z vodo in NaOH.

Ali mi lahko kdo razloži metriko tega drugačnega drugega koraka? Swim še nikoli ni delal na ta način, vendar se zdi, da prihrani veliko časa v nasprotju s staro metodo z refluksiranjem HCl.

Kakšna je moč jedke snovi/vode in koliko se je vnese v reaktor na L proizvoda?
Kako dolgo je treba kuhati to reakcijsko zmes pri kateri temperaturi?

 

[waltjr5858]

You can do hydrolysis with a base or an acid...

 

[G.Patton]

Ali uporabljate povratni hladilnik in digestor?

 

[waltjr5858]

In a write up that most people are reading to do this leuckart with formamide and p2p specifically... what is the purpose of a 15 min reflux with 30% h2O2 with the reaction mixture after you have already done the first reflux with formamide and p2p. Does it clean up or oxidize something? I mean this is prior to the hydrolysis. I just can't think of what it would do. I mean most people do it without it but it was obviously added for a reason in a actual professional write-up.

 

[G.Patton]

Sorry, but I don't clearly understand about what "15 mix reflux" are you talking about? Can you be more precise. Refer to a step number.

 

[waltjr5858]

It's not on these instructions. When making amphetamine after the first 24 hour reflux on a different set of instructions they would reflux for 15 minutes with 30% hydrogen peroxide and then go on with hydrolysis. What was the point of the peroxide?

 

[G.Patton]

I have no Idea about what "different set of instructions" are you talking and hence can't answer your question.

 

[waltjr5858]

Ok... but in general then what would happen to the resulting solution if spun up with 30% peroxide?

 

[TheNut22]

Svoje močnejše vodikove perokside sem izdelal iz 12-odstotnega H2O2. Iz njega sem samo previdno izparil vodo.
Za izračune sem prosil pomočnika z umetno inteligenco - robota na področju kemije. Pri izračunih je dober, vendar ne pričakujte, da bo dobil pravilne odgovore
iz halogenacij ali podobnega ...

 

[loadingST]

Reakcije še nisem preizkusil, vendar bi z dobro hidrolizo s KOH in nato s HCL morala dati visok izkoristek, bojim pa se, da bi delal s h2o2, da ne bi nastali eksplozivni peroksidi, in da ne bi ob destilaciji eksplodirali.

 

[William D.]

Yes, it is better to exclude peroxide.

 

[YenaneY]

This questions are mainly regarding the actual chemistry behind the synthesis...
Why does one for the formation of the amine from the intermediate need H2O2 and HCl in the synthesis of amphetamine but only HCl in the synthesis of methamphetamine?

 

[William D.]

In fact, there is no need to use peroxide.

 

[waltjr5858]

But what was the purpose of the peroxide in the first place I believe he's asking

 

[Pinkbay]

sir, In step 3, is heating required?

 

[rampage]

can you replace n-methylformamide with dimethylformamide?